There’s no debate about which game is the highlight of Week 10 in college football.
Fans of college football have had the Week 10 Ohio State vs. Penn State matchup circled on their calendars since this summer.
Now that November 2 has arrived, with reigning national champ Michigan struggling amid massive roster turnover from a year ago, the winner of this game will have the inside track to the Big Ten Championship Game, and possibly the 12-team College Football Playoff.
The clash between the No. 4 Buckeyes and No. 3 Nittany Lions kicks off at noon Eastern on FOX, with all eyes on Happy Valley.
Ohio State vs. Penn State Betting Odds
Below are the odds for Ohio State vs. Penn State in three key markets: the spread, moneyline and total.
| DraftKings | FanDuel | bet365 | |
| OSU spread | -3 (-112) | -3.5 (EVEN) | -3 (-115) |
| PSU spread | +3 (-108) | +3.5 (-122) | +3 (-105) |
| OSU ML | -162 | -154 | -165 |
| PSU ML | +136 | +128 | +140 |
| Total | 47.5 (o-108; u-112) | 47.5 (o-115; u-105) | 47.5 (o-110; u-110) |
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Ohio State vs. Penn State Betting Preview
Ohio State Betting News, Analysis
The Buckeyes entered this season ranked No. 2 in the preseason AP Top 25, and they were a popular national title pick given all the talent on this roster. This year’s Ohio State team likely features not only several players who will be selected in the 2025 NFL Draft, but more than a few others who will be taken in 2026 and 2027.
From RBs Quinshon Judkins and TreVeyon Henderson to WRs Jeremiah Smith and Emeka Egbuka, to name just a few, head coach Ryan Day has an embarrassment of riches at his disposal.
But the Buckeyes had a rough October, at least relative to this program’s sky-high expectations, losing a thriller to now-No. 1 Oregon in Eugene before struggling at home vs. Nebraska last Saturday. OSU ended up surviving the Cornhuskers’ upset bid, but never managed to pull away from 5-3 (2-3 Big Ten) Nebraska.
This team dealt with O-line injuries last week, and it will be without starting left tackle Josh Simmons for the rest of the year. His backup, Zen Michalski, struggled last week, and whether it’s Michalski or Option C at LT, the talented Penn State D-line led by DEs Abdul Carter and Dani Dennis-Sutton will be licking its chops.
Penn State Betting News, Analysis
Penn State is undefeated and could actually reach the Big Ten title game even if it loses today. But good luck convincing anyone associated with this program that this is not a must-win for coach James Franklin.
The veteran Nittany Lions coach has done just about everything in Happy Valley except knock off the Buckeyes and Wolverines — he’s 1-9 against the former, with the lone win coming back in 2016.
Oddsmakers remain bullish on the talent up and down the OSU roster winning out in this game. Penn State, however, has been the better team this year. That would make a loss today, especially if Drew Allar is healthy, a bitter pill for the Nittany Lions to swallow.
Penn State has wins over USC, Illinois and Wisconsin this year, but this is the first truly elite opponent this team has faced. If Allar, a former five-star recruit who has been outstanding this season, is active, don’t be surprised if Penn State pulls off the breakthrough upset given the way the Ohio State O-line has struggled against good defenses this season.
It’s worth noting that in last week’s win over Wisconsin, QB Beau Pribula played well when called upon following a knee injury that ended Allar’s night early. Pribula’s play fueled optimism that even if Allar is less than 100 percent, PSU will still be able to move the football.
Ohio State vs. Penn State Prediction
No one familiar with this rivalry could be blamed for doubting Penn State given recent history, but Ohio State has so far looked like less than the sum of its parts.
Assuming Allar is good to go, we like Penn State to grind out a low-scoring win in front of a raucous crowd to move one step closer to the program’s first Big Ten Championship Game appearance since 2016.
Ohio State vs. Penn State Best Bets
We’ve got a few plays we feel good about in this one.
While both these offenses feature several future pros, we expect this to be a low-scoring game.
Anyone tempted to take the over should keep in mind that most of Penn State’s biggest games in recent years have been slugfests (21-7 over Illinois earlier this year, 28-13 over Wisconsin last week, not to mention last year’s 20-12 loss to the Buckeyes and 24-15 loss to Michigan).
As we’ve hinted at, we like Penn State to win this game, and we’re also confident that even if the Nittany Lions end up failing to come out on top, they’ll start off strong, hence the half-unit wager on the home team leading this game at the half.
- Under 47.5 (-110 at bet365) 1 unit
- Penn State moneyline (+140 at bet365) 1 unit
- Penn State 1H moneyline (+120 at DraftKings) 0.5 units
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